Current and Recent Federal, Foundation and Industry Funded Grants
VPSD Barrett (Scholar) 07/01/08 - 05/31/10
Vanderbilt University Physician Scientist Development Program Award
A Randomized, Double Blind, and Placebo-Controlled Trial Comparing Ondansetron, Metoclopramide and Promethazine for Treatment of Nausea and Vomiting in the Adult Emergency Department
The goal of this study is to determine whether ondansetron has superior nausea reduction compared to metoclopramide, promethazine, or saline placebo in emergency department adults with undifferentiated nausea.
NIH/NHLBI K23-HL-102069 Barrett (PI) 06/01/2010-09/30/2015
Improving Atrial Fibrillation Risk Stratification in the ED
The goal of this study is to develop and validate a multivariable clinical prediction rule that accurately estimates risk for adverse outcome in emergency department patients with atrial fibrillation. We will describe and analyze the rule’s utility by the distribution of assigned risk and its impact on physician decision-making.
PCORI FC14-1409-21656 Collins (PI) 10/15/2015-10/14/2018
GWTG Interventions to Reduce Disparities in Acute HF Patients Discharged from the ED (GUIDED HF)
The project will evaluate the benefits of a Get With the Guidelines-HF based, tailored transitional care intervention for acute heart failure patients scheduled for discharge after a bried period of observation from the emergency department.
NIH/NHLBI K12 HL109019-02 Storrow (PI); Collins (co-PI) 07/01/2011-06/30/2016
The Vanderbilt Emergency Medicine Research Training Program” Career development program for emergency medicine
NIH/NHLBI (R01-HL-088459) Storrow (PI); Collins (Co-I) 2007-2011
Improving Heart Failure Risk Stratification in the ED (STRATIFY)
The purpose of this study was to develop and validate a prediction rule for ED patients with signs and symptoms of acute heart failure.
NIH / NHLBI (K23-HL-085387) Collins (PI) 2008-2014
Treatment Endpoints in Acute Decompensated Heart Failure (DECIDE)
The goal of this project was to develop a prediction rule from readily available clinical data to help physicians identify patients with acute heart failure eligible for safe and early discharge from the ED and hospital after treatment is initiated.
NIH / NHLBI K12HL109019 Storrow (PI); Han (Scholar) 2011 – 2016
“The Vanderbilt Emergency Medicine Research Training Program” Career development program for emergency medicine.
Dr. Han is a part of a career development program (K12) sponsored by the National Heart, Lung, and Blood Institute. As part of this K12 program, he is determining how cognitive impairment (delirium and dementia) effects 30-day resource utilization.
NIA / NIA K23AG032355 Han (PI) 2010 - 2015
Delirium in the Emergency Department: Novel Screening and Natural Course
This is a career development award (K23) from the National Institute on Aging to validate novel and brief delirium assessments specifically tailored for the busy emergency department environment. This grant also sought to characterize the natural course of delirium in the emergency department and determine how its persistence into hospitalization effects 6-month function.
NHLBI K12HL109019 Storrow (PI), Gupta (scholar) 2011-2016
The Vanderbilt Emergency Medicine Research Training Program (VEMRT)
The Major Goal of this project is to train a new generation of scientists to address the compelling public health challenges in the management of acute heart, lung, blood, and traumatic diseases.
NHLBI K23HL128928 Gupta (PI) 2016-2020
The natriuretic peptide system in African-Americans. The major goal of this career development award is for the principal investigator to acquire the skills and unique expertise needed to transition into an independent investigator. During the course of the award, the PI will (1) assess the natriuretic peptide response to dietary salt loading in African-American individuals compared with white individuals and (2) examine the genetic basis for natriuretic peptide levels in African-Americans.
NIH/NHLBI K23HL125670 McNaughton (PI) 2015-2018
A Randomized, ED-based Intervention to Improve Antihypertensive Adherence
This 3-year grant develops and tests an ED-based behavioral intervention aimed at improving antihypertensive adherence at 30 and 90 days among 350 primary care patients with hypertension who seek ED care.
NIH/NHLBI K12 HL109019 Storrow (PI); McNaughton (Scholar) 2012-2015
The Vanderbilt Emergency Medicine Research Training Program (VEMRT)
During the K12 fellowship, Dr. McNaughton published 22 peer-reviewed manuscripts, presented at 6 national meetings, and completed qualifying requirements for the Vanderbilt University Epidemiology doctoral program.
NHLBI K12HL109019 Storrow (PI), Muñoz (scholar) 2013-2016
The Vanderbilt Emergency Medicine Research Training Program (VEMRT)
During the K12 fellowship, Dr. Muñoz played a key role in the ongoing preparation of an R01 application to the NHLBI that seeks to identify novel strategies in the ED-based evaluation of patients with low-risk chest pain. The K12 also supported his development and participation in the team-based science outline below.
PCORI Muñoz (Site Co-PI) 2015-1018
Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-term Effectiveness (ADAPTABLE)
Goal: To identify the optimal dose of aspirin in a high-risk secondary prevention population of patients with coronary heart disease
NIH / NIGMS K23GM110469 Self (PI) 2015 – 2019
Salivary Cortisol as a Marker of Community-Acquired Pneumonia Severity in Adults.
This is a career development award (K23) from the National Institute of General Medical Sciences (NIGMS) to investigate how a novel biomarker, salivary cortisol, can improve a clinician’s ability to understand a patient’s risk for severe pneumonia-related outcomes.
NIH / NHLBI U01 HL123033 Rice (PI); Self (Co-PI) 2014 - 2021
Clinical Coordinating Center for the Prevention and Early Treatment of Acute Lung Injury (PETAL) Clinical Trials Network.
In the NHLBI PETAL Network, we develop and conduct randomized controlled trials to prevent, treat, and improve the outcomes of patients with or at risk for acute lung injury. This network builds on the strengths and experiences of the successful ARDS Network, and shifts the focus of interventions toward prevention and earlier treatment of lung injury.
NIH / NCATS KL2TR000446 Bernard (PI); Self (Scholar) 2012 – 2014
Multicenter implementation and evaluation of a quality improvement program to reduce blood culture contamination in the emergency department.
This was a KL2 mentored career development award funded through the Vanderbilt Clinical and Translation Science Award (CTSA) to evaluate the effectiveness of a quality improvement toolkit for reducing blood culture contamination in community hospital emergency departments (Acad Emerg Med 2014; 21:274-282).
NIH / NHLBI K12HL109019 Storrow (PI); Ward (Scholar) 2011 – 2016
“The Vanderbilt Emergency Medicine Research Training Program” Career development Program for Emergency Medicine.
Dr. Ward was a part of a career development program (K12) sponsored by the National Heart, Lung, and Blood Institute. As part of this K12 program, he examined the timeliness of acute coronary syndrome, and heart failure treatment in the emergency department.
NIH / NHLBI K23HL127130 (NHLBI) Ward (PI) 2016 - 2019
Enhancing Inter-Facility Transfer for Patients with Acute Myocardial Infarction
This is a career development award (K23) from the National Heart Lung and Blood Institute (NHLBI) to investigate of timeliness of inter-facility transfer for patients with ST-elevation myocardial infarction. This work focuses on understanding how facilities transfer patients and
how coordination affects timeliness.
NIH / NHLBI K12HL109019 Storrow (PI); Yiadom (Scholar) 2014-2016
Improving the Screening Criteria for an Early ECG to Diagnose STEMI
Dr. Yiadom is investigating methods to improve screening for an early ECG to diagnose STEMI. Earlier diagnosis and treatment is associated with reduced mortality and better outcomes. As a result the goal is to obtain an early ECG within 10 minutes of arrival. However, the criteria used to identify which arriving patients get an early ECG are highly variable across EDs. This study hypothesis is that facility, patient population, and screening process characteristics influence the performance of ED screening criteria. This information can be used to better tailor STEMI screening criteria to avoid delays in STEMI diagnosis.
Rehn Family Grant Collins (PI) 2008-2009
The Association of CD 14 Levels with the Development of Abdominal Aortic Aneurysm
The goal in this grant was to investigate the relationship of serum CD 14 levels with human abdominal aortic aneurysm (AAA) and to characterize CD 14 expression in human AAA tissues.
University of Cincinnati Dean’s Discovery Fund Collins (PI) 2005-2006
Identifying Treatment Variables Associated with Subsequent Adverse Events in Decompensated Heart Failure: A Pilot Study
The major goal of this study is to test the feasibility of collecting prospective data and identify predictors of adverse events in the first 24 hours of therapy in ED heart failure patients.
Emergency Medicine Foundation Acute Heart Failure Storrow (PI); Collins (Co-I) 2003
Emergency Department Observation Versus Inpatient Admission for Therapy of Acute Congestive Heart Failure
The major goal of this pilot project was to address the identification and cost analysis issues surrounding Observation Unit management of CHF so that initial treatment and appropriate disposition can be facilitated.
Society for Academic Emergency Medicine Self (PI) 2011 – 2012
A patient safety initiative to minimize blood culture contamination in the ED.
This multicenter quality improvement study was funded by the Patient Safety Research Fellowship Grant from the Society for Academic Emergency Medicine and Emergency Medicine Patient Safety Foundation. We evaluated the effectiveness of a quality improvement toolkit for reducing blood culture contamination in community hospital emergency departments (Acad Emerg Med 2014; 21:274-282).
Emergency Medicine Foundation Ward (PI) 2011 – 2013
Going Paperless: Understanding Emergency Department Operational Performance During Electronic Health Record Implementation.
This was a research fellowship award from the Emergency Medicine Foundation. This study examined operational disruption of emergency department performance caused by electronic health record implementation.
MAJOR INDUSTRY GRANTS & CONTRACTS
RIVAROXAFL4002 Barrett (Site PI) 06/01/2014-05/30/2016
Janssen Scientific Affairs, LLC
This prospective registry, Phase II of the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF II), is designed to evaluate the utilization of target-specific antithrombotic agents, such as factor Xa (FXa) inhibitors and direct thrombin inhibitors, and associated outcomes.
Alere Barrett (Site PI) 2015-2016
This study investigated the performance of multiple point-of-care INR platforms in patients with supratherapeutic INRs.
Novartis Collins (Co-PI; Executive Director - DCC) 2014-ongoing
EMROC (Emergency Medicine Research and Outcomes Consortium)
This is a network of acute heart failure ED researchers which is developing a large registry of ED patients with acute heart failure for the purposes of describing patterns in early management decisions.
Novartis Collins (PI) 4/15/2016-3/1/2017
Identifying Diuretic Resistance in Patients with Acute Heart Failure
This study evaluates early urinary sodium to identify patients who will develop diuretic resistance.
Inovise Medical, Inc. Collins (PI) 2005 – 2006
HEart failure and Audicor technology for Rapid Diagnosis and Initial Treatment: HEARD-IT Trial
The major goal of this international, multi-center industry sponsored study was to compare 15 minute emergency department diagnostic accuracy with the 15 minute diagnostic accuracy of the Audicor S3 heart sound data in patients presenting to the Emergency Department with dyspnea.
Novartis Gupta (Site PI) 2015-2021
PARAGON HF - a multicenter, randomized, double-blind, parallel group, active-controlled study to evaluate the efficacy and safety of LCZ696.
The major goal of this study is to test the hypothesis that LCZ696 is superior to valsartan alone in reducing heart failure hospitalizations or cardiovascular death in patients with heart failure and preserved ejection fraction.
Novartis Inc. Han (Vanderbilt site-PI) 2015 – 2021
International Registry to Assess Medical Practice with Longitudinal Observation for Treatment of Heart Failure (REPORT-HF)
This is a global, multicenter, prospective cohort study that will enroll 20,000 patients with acute heart failure. This study seeks to characterize acute heart failure therapy patterns during hospitalization and post-discharge events such as healthcare resource utilization and quality of life.
Novartis Inc. Han (Vanderbilt site-PI) 2015 – 2017
A multicenter, randomized, double-blind, placebo controlled phase IIIb study to evaluate the efficacy, safety and tolerability of Serelaxin when added to standard therapy in acute heart failure patients.
The purpose of this study is to evaluate the efficacy, safety and tolerability of intravenous infusion of serelaxin when added to standard therapy in approximately 6,800 acute heart failure (AHF) patients. Efficacy will be determined based on the relative reduction in cardiovascular death, worsening heart failure and other clinical outcomes through a follow-up period of 180 days, as compared to placebo.
BioAegis, Inc Self (PI) 2014 – 2016
Evaluation of plasma gelsolin as a marker of clinical outcomes and etiology in adults hospitalized with community-acquired pneumonia.
This is an investigator-initiated, industry-sponsored multicenter study to evaluate plasma gelsolin as a marker of disease severity and etiology in adults with community-acquired pneumonia.
Pfizer Self (Vanderbilt site-PI) 2013 – 2016
Streptococcus pneumoniae serotypes in adults 18 years and older with radiographically-confirmed community-acquired pneumonia (CAP) [Pfizer protocol: B1851147].
This was a multicenter prospective cohort study to determine the prevalence of pneumococcal serotypes in adults with community-acquired pneumonia in the United States.
Rapid Pathogen Screening, Inc. Self (Vanderbilt site-PI) 2014 – 2016
Clinical performance of FebriDx in patients being evaluated for acute community acquired febrile respiratory infection (protocol #: 13-0830).
This is a multicenter prospective study to evaluate the accuracy of a novel point-of-care biomarker panel for distinguishing between bacterial and viral respiratory infections.
BRAHMS GmbH / Thermo Fisher Self (Vanderbilt site-PI) 2013 – 2014
Procalcitonin decrease over 72 hours and outcome in patients with severe sepsis or septic shock.
This was a multicenter prospective cohort study to evaluate the predictive performance of changes in procalcitonin levels for clinical outcomes in severe sepsis.
Abbott Point of Care, Inc. Ward (Site PI) 2014 - 2015
Cost-Effectiveness Analysis of Point of Care Lactate Testing to Identify Severe Sepsis in the Emergency Department.
This study was an investigator-initiated cost-effectiveness analysis of point of care testing for patients with severe sepsis presenting to the emergency department.